In Switzerland, around 400,000 people are affected by the disease, mostly older people; the female sex predominates due to hormonal changes during the menopause. However, due to increasing life expectancy, men also suffer from osteoporosis nowadays. Although the decline in bone density is a physiological process that begins in women during the menopause, it often only manifests itself years later in the form of a fracture. "Hereditary factors, smoking, hormonal disorders and certain medications, such as long-term cortisone treatment, can accelerate this reduction process," explains Dr Anna Thoma, Deputy Head of Rheumatology and Pain Medicine at Bethesda Hospital. The decline in bone density goes unnoticed, and the diagnosis is often only made when a fracture occurs. Vertebral body fractures can occur without any external force, such as a fall, and present with acute pain in the back. However, fractures in the thoracic or lumbar spine can also occur unnoticed, but then lead to unfavourable statics or a deformity of the spine over time.